Lab Members: Mike Strauss

Post-doctoral Fellow Building C2-130 240 Longwood Ave Boston, MA 02115 617-432-3839 (lab) mikestrauss13[at]crystal.harvard.edu

Mike studied under the tutelage of Peter Ottensmeyer (UToronto) and Werner Kühlbrandt (MPI-Biophysics, Frankfurt), and has specialised in cryo electron microscopy and methods development in electron tomography. He has worked on mitochondria, membrane proteins, cyanobacteria, bacterial spores, enzyme complexes, and chromatin structure. These days he plies his trade in the field of picornavirus cell entry by cryoEM and the structure determination of nanobodies.

Selected Publications:

• Schotte, L., Thys, B., Strauss, M., Filman, D.J., Rombout, B., Hogle, J.M., Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs), Antimicrobial Agents and Chemotherapy (2015), 59(8):4695-706.
• Strauss, M., Filman, D.J., Cheng, N., Noel, R.T., Belnap, D.M., Hogle, J.M., Nectin-like interactions between Poliovirus and its receptor trigger conformational changes associated with cell entry, J Virology (2015), 89(8):4143-57.
• Panjwani, A., Strauss, M., Gold, S., Wenham, H., Jackson,T., Chou, J.J., Rowlands, D.J., Stonehouse, N.J., Hogle, J.M., Tuthill, T.J., Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore, PLoS Pathogens (2014) 10(8): e1004294.
• Schotte, L., Strauss, M., Thys, B., Halewyck, H., Filman, D.J., Bostina, M., Hogle, J.M., Rombaut, B., Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity, J Virology (2014) 88(8):4403-13
• Ma H-C, Liu Y, Wang C, Strauss, M., Rehage, N, Hogle, J.M., Wimmer, E., Mueller, S., Paul, A. V., Jiang, P. An Interaction between Glutathione and the Capsid Is Required for the Morphogenesis of C-Cluster Enteroviruses. PLoS Pathog (2014) 10(4): e1004052. doi:10.1371/journal.ppat.1004052.
• Strauss, M., Levy, H., Bostina, M., Filman, D.J., Hogle, J.M., RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors, J Virology (2013) vol 87(7):3903-14.
• Mills, D.J., Vitt, S., Strauss, M., Shima, S., Vonck, J., De novo modelling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy, eLife (2013) vol 2: p. e00218.
• Fussner, E.*, Strauss, M.*, Djuric, U., Li, R., Ahmed, K., Hart, M., Ellis, J., Bazett-Jones D., Open and closed domains in the mouse genome are configured as 10 nm chromatin fibres, EMBO Reports (2012) Sept 18, vol 13(11):992-6.
• Davies, K.*, Strauss, M.*, Daum, B.*, Kief, J., Rycovska, A., Osiewacz, H., Zickermann, V., Kühlbrandt, W., Macromolecular organisation of ATP synthase and complex I in whole mitochondria, PNAS (2011) Aug 23;108(34):14121-6.
• Strauss, M.*, Hofhaus, G.*, Schröder, R.R., Kühlbrandt, W, Dimer Ribbons of ATP Synthase Shape the Inner Mitochondrial Membrane, EMBO Journal (2008), v27 (7) pp. 1154-60.